Plastic packaging and commonly used plastic materials for pharmaceutical packaging

申佳液压


Release time:

2023-05-25

Plastic is one of the main packaging materials, and the history of its application in drug packaging is not very long. The many advantages of plastic determine that it has played and will play a major role in drug packaging. These advantages include light weight, not easily broken, easy to use, gas barrier effect, easy combination of different plastics and plastics with other materials, mature molding process, and so on.

Plastic packaging and commonly used plastic materials for pharmaceutical packaging

1、 Plastic

Plastic is one of the main packaging materials, and the history of its application in drug packaging is not very long. The many advantages of plastic determine that it has played and will play a major role in drug packaging. These advantages include light weight, not easily broken, easy to use, gas barrier effect, easy combination of different plastics and plastics with other materials, mature molding process, and so on.

1. Plastic resin Plastic resin is a plastic polymer compound that can be roughly divided into two categories based on its structure and properties: thermosolid resin and thermoplastic resin. Most pharmaceutical plastic packaging uses thermoplastic resin.

2. Additives

Resin is the main component of plastic. In the plastic manufacturing process, various additives need to be added, such as plasticizer, antioxidant, antistatic agent, lubricant, colorant, heat stabilizer, etc.

2、 The Relationship between Plastic Packaging Materials and Drugs

Drugs are a special commodity that, as packaging materials (or containers) that come into direct contact with drugs, must ensure the safety, efficacy, and stable quality of the drugs, while also meeting the convenience needs of patients for medication.

The adaptability between plastic packaging materials (containers) and the packaged drugs is a problem that drug manufacturers must solve when selecting packaging materials. Light, heat, humidity, microorganisms, oxygen, and mechanical impact can all have adverse effects on drug quality. The purpose of packaging is to defend against the impact of these external factors on drug quality to a certain extent. This involves a barrier issue, including the barrier to light, microorganisms, and gases. The purpose of plastic bottle made into brown yellow or white bottle made by adding titanium dioxide is to block light. The inclusion of aluminum foil in the composite film not only greatly improves the barrier to gas, but also completely blocks light.

Solid drug substrates are generally loose materials, so they are processed into tablets, capsules, and other preparations for easy consumption. Many drugs are crystalline or amorphous powders that are prone to moisture absorption and deliquescence before being made into tablets or capsules. Solid formulations are susceptible to varying degrees of influence from water vapor and oxygen during storage, which can alter their quality. Reduce the content, change the release rate, and so on.

At present, solid oral formulations are commonly packaged in bottles (mostly plastic bottles), blister packaging, strip packaging, and other packaging forms. For plastic bottles, in addition to material selection, it is necessary to have a certain thickness and thickness uniformity, and the sealing of the bottle mouth is excellent. For blister packaging, the formed hard sheet must have a certain thickness. If the PVC hard sheet cannot meet the temperature resistance requirements, PET hard sheet or PVC/PVDC composite hard sheet can be used instead. The other layer of blister packaging is aluminum foil used for drug packaging, and the quality of the original foil used is good. It is generally believed that a thickness of 0.025mm or above is necessary to have no pinholes. The selection of materials for various composite films used in strip packaging should be carefully selected based on the characteristics of the drug. The packaging of liquid oral liquid is still mainly in glass bottles and plastic bottles. Oral liquid plastic bottles are generally made of PP or PET, which can provide sufficient mechanical strength, avoid mechanical damage, and provide a certain degree of gas barrier and microbial barrier. Especially PET bottles